A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression

A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression

Background: Activation of nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in gout. Selaginella moellendorffii has been confirmed effective for the treatment of gout in hospital preparations. Flavonoids, such as amentoflavone (AM), are the main acti...

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Bibliographic Details
Main Authors: Xueyan Zhang, Yingbo Liu, Guangrui Deng, Bisheng Huang, Guoyin Kai, Keli chen, Juan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Selaginella moellendorffii
biflavonoid
amentoflavone
NLRP3
gout
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.676297/full

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