BICP0 Negatively Regulates TRAF6-Mediated NF-κB and Interferon Activation by Promoting K48-Linked Polyubiquitination of TRAF6

BICP0 Negatively Regulates TRAF6-Mediated NF-κB and Interferon Activation by Promoting K48-Linked Polyubiquitination of TRAF6

The infected cell protein 0 (BICP0) is an immediate early protein encoded by BHV-1, and its RING finger domain, which endows BICP0 with intrinsic E3 ubiquitin ligase activity, is common in all ICP0 proteins. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is one of the TRAF family members...

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Bibliographic Details
Main Authors: Chong Cao, Ran An, YueYang Yu, HaiYue Dai, ZheHui Qu, MingChun Gao, JunWei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
BICP0
TRAF6
interferon
NF-κB
motif
ubiquitin
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03040/full

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