P-cadherin expression and survival rate in oral squamous cell carcinoma:an immunohistochemical study

• Main Authors: Laino Gregorio, Serpico Rosario, Pannone Giuseppe, Rubini Corrado, Farina Antonio, Campisi Giuseppina, Lo Muzio Lorenzo, De Lillo Alfredo, Carinci Francesco
• Format: Article
• Language: English
• Published: BMC 2005-06-01
• Series: BMC Cancer
• Online Access: http://www.biomedcentral.com/1471-2407/5/63

<p>Abstract</p> <p>Background</p> <p>P-cadherin (P-cad) is a transmembrane molecule involved in the cell-cell adhesion and similar to E-cadherin (E-cad), but less investigated in oncology, especially in <it>in vivo </it>studies. Aims of the present study were to assess the prevalence of P-cad expression in oral squamous cell carcinoma (OSCC) and to verify whether P-cad can be considered a marker of prognosis in patients with OSCC.</p> <p>Methods</p> <p>In a retrospective study, a cohort of 67 OSCC patients was investigated for P-cad expression and its cellular localization by immunohistochemistry; some respective healthy margins of resection were similarly investigated as standard controls. After grouping for P-cad expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, Staging, and overall survival rate. Univariate and multivariate analyses were performed.</p> <p>Results</p> <p>37 cases (55.2%) of OSCC showed membranous/cytoplasmic positivity for P-cad, whereas 30 (44.8 %) were negative. Although with some differences in membranous vs cytoplasmic localization of P-cad in OSCC with different G, no statistical association was found between P-cad expression and any variables considered at baseline. In terms of prognostic significance, P-cad non expression was found to have an independent association with poorer overall survival rate than P-cad expressing group (P = 0.056); moreover, among P-cad +ve patients the best prognosis was for those OSCC with membranous (P < 0.0001) than those with cytoplasmic P-cad expression.</p> <p>Conclusion</p> <p>On the basis of these results, it is possible to suggest P-cad as an early marker of poor prognosis. The abnormal or lack of P-cad expression could constitute an hallmark of aggressive biological behavior in OSCC</p>