The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

The activity of the Salt inducible kinase 2 (SIK2), a member of the AMP-activated protein kinase (AMPK)-related kinase family, has been linked to several biological processes that maintain cellular and energetic homeostasis. SIK2 is overexpressed in several cancers, including ovarian cancer, where i...

Full description

Bibliographic Details
Main Authors:	Monika Raab, Marcel Rak, Roberta Tesch, Khayal Gasimli, Sven Becker, Stefan Knapp, Klaus Strebhardt, Mourad Sanhaji
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Cancers
Subjects:	Salt inducible kinase 2 (SIK2) the small molecule inhibitor MRIA9 spindle mispositioning chromosomal instability ovarian cancer paclitaxel sensitization
Online Access:	https://www.mdpi.com/2072-6694/13/15/3658

Similar Items

Σχεδιασμός και ανάπτυξη νέων συνθετικών αναλόγων του χ-κωνοπεπτιδίου MrIA
by: Μερτζιάνη, Βασιλική
Published: (2014)

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency
by: Rebekah Ziegman, et al.
Published: (2019-03-01)

SIK1-LNC represses the proliferative, migrative, and invasive abilities of lung cancer cells
by: Yang L, et al.
Published: (2018-07-01)

SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells
by: Chang Wang, et al.
Published: (2020-09-01)

MicroRNA-17 promotes cell proliferation and migration in human colorectal cancer by downregulating SIK1
by: Huang C, et al.
Published: (2019-04-01)

Safety and efficacy of navigated trocarless pedicle screw placement: Technical note
by: Giuseppe Emmanuele Umana, et al.
Published: (2020-09-01)

M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3
by: Yuan Xiong, et al.
Published: (2020-04-01)

Overexpression of SikRbcs2 gene promotes chilling tolerance of tomato by improving photosynthetic enzyme activity, reducing oxidative damage, and stabilizing cell membrane structure
by: Li Zhang, et al.
Published: (2020-07-01)

People and Plant Interaction in Central Anatolian Early Neolithic Communities : plant consumption and agriculture at A¸sıklı Höyük
by: Ergun, Müge
Published: (2016)

Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel
by: Huang T, et al.
Published: (2017-01-01)

Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1
by: Moataz Badawi, et al.
Published: (2021-07-01)

Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non–small cell lung cancer cells
by: Yuan-Hu Yao, et al.
Published: (2016-06-01)

CircAMOTL1 Promotes Tumorigenesis Through miR-526b/SIK2 Axis in Cervical Cancer
by: Zhengwei Sun, et al.
Published: (2020-12-01)

Role of SIK1 in the transition of acute kidney injury into chronic kidney disease
by: Jinxiu Hu, et al.
Published: (2021-02-01)

SIK2 represses AKT/GSK3β/β‐catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases
by: Xiao‐man Dai, et al.
Published: (2021-01-01)

Studi Eksperimental Perilaku Siklis Flat Sab Beton Mutu Sangat Tinggi
by: Ruddy Kurniawan, et al.
Published: (2014-08-01)

Regulation of StAR by the N-terminal domain and co-induction of SIK1 and TIS11b/Znf36l1 in single cells.
by: Jinwoo Lee, et al.
Published: (2016-08-01)

MYBL2-induced PITPNA-AS1 upregulates SIK2 to exert oncogenic function in triple-negative breast cancer through miR-520d-5p and DDX54
by: Bolong Liu, et al.
Published: (2021-08-01)

Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
by: Kosai, Azuma
Published: (2020)

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers
by: Ailsa Bennett, et al.
Published: (2016-01-01)

Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1
by: Cai, H., et al.
Published: (2022)

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
by: Floris Foijer, et al.
Published: (2017-03-01)

Cancer metastasis: issues and challenges
by: Chao-Nan Qian, et al.
Published: (2017-04-01)

Spridningsbegränsningar för sik (Coregonus lavaretus) : En GIS-baserad studie
by: Dynesius, Aron
Published: (2021)

An Architectural Solution of Assistance e-Services for Diabetes Diet
by: Vasile AVRAM, et al.
Published: (2011-01-01)

Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy
by: Fangyu Chen, et al.
Published: (2019-01-01)

A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin
by: Dengxuan Fan, et al.
Published: (2021-01-01)

A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells
by: Marcella L Erb, et al.
Published: (2014-11-01)

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
by: Naoto Hayasaka, et al.
Published: (2017-12-01)

Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel
by: Joana Fonseca, et al.
Published: (2016-07-01)

Effect of Ect2 Expression on the Growth of Triple-Negative Breast Cancer Cells with Paclitaxel Intervention
by: Wang H, et al.
Published: (2020-12-01)

Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
by: Angela Lauriola, et al.
Published: (2020-04-01)

In vitro effects of 2-methoxyestradiol, an endogenous estrogen, on MCF-12A and MCF-7 cell cycle progression
by: Van Zijl, Magdalena Catherina
Published: (2013)

STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association
by: Michele Campaigne Larsen, et al.
Published: (2020-10-01)

Uncoupling of DNA Replication and Centrosome Duplication Cycles Is a Primary Cause of Haploid Instability in Mammalian Somatic Cells
by: Koya Yoshizawa, et al.
Published: (2020-07-01)

Primary pleural liposarcoma combined spindle cell lipoma of the lung
by: Lae Hyung Kang, et al.
Published: (2020-07-01)

Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells
by: Schermuly, Nadine
Published: (2020)

Hemi facial spasm
by: A. V. Ciurea, et al.
Published: (2007-03-01)

Fancc regulates the spindle assembly checkpoint to prevent tumorigenesis in vivo
by: Edwards, Donna Marie
Published: (2017)

Anaphase Chromosomes in Crane-Fly Spermatocytes Treated With Taxol (Paclitaxel) Accelerate When Their Kinetochore Microtubules Are Cut: Evidence for Spindle Matrix Involvement With Spindle Forces
by: Arthur Forer, et al.
Published: (2018-07-01)