The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

The activity of the Salt inducible kinase 2 (SIK2), a member of the AMP-activated protein kinase (AMPK)-related kinase family, has been linked to several biological processes that maintain cellular and energetic homeostasis. SIK2 is overexpressed in several cancers, including ovarian cancer, where i...

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Bibliographic Details
Main Authors: Monika Raab, Marcel Rak, Roberta Tesch, Khayal Gasimli, Sven Becker, Stefan Knapp, Klaus Strebhardt, Mourad Sanhaji
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
Salt inducible kinase 2 (SIK2)
the small molecule inhibitor MRIA9
spindle mispositioning
chromosomal instability
ovarian cancer
paclitaxel sensitization
Online Access:https://www.mdpi.com/2072-6694/13/15/3658

Internet

https://www.mdpi.com/2072-6694/13/15/3658

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