Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats

Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats

Abstract Background Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological function and in treatment-induced improvements in function. Microglia and astrocytes influence this process through direct inte...

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Bibliographic Details
Main Authors: Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Richard J. Woodman, Hakan Muyderman, Neil R. Sims
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
Focal ischemia
Microglia
Astrocytes
Olomoucine
Cell cycle inhibition
Online Access:https://doi.org/10.1186/s12974-021-02208-w

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