RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.

Resection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about processing of random "dirty-ended" DSBs created by DNA damaging agents s...

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Bibliographic Details
Main Authors: Jim Westmoreland, Wenjian Ma, Yan Yan, Kelly Van Hulle, Anna Malkova, Michael A Resnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Genetics
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19763170/pdf/?tool=EBI

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