Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased mucociliary clearance, bacterial colonisation, and chronic neutrophil-dominated inflammation. Much knowledge surr...

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Bibliographic Details
Main Authors:	Gillian M. Lavelle, Michelle M. White, Niall Browne, Noel G. McElvaney, Emer P. Reeves
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2016/5258727

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