Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage.

Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage.

Current approaches for DNA extraction and fragmentation from mammalian spermatozoa provide several challenges for the investigation of the oxidative stress burden carried in the genome of male gametes. Indeed, the potential introduction of oxidative DNA damage induced by reactive oxygen species, red...

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Bibliographic Details
Main Authors: Miguel J Xavier, Brett Nixon, Shaun D Roman, Robert John Aitken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5868848?pdf=render

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