Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Obesity has been implicated as a risk factor for insulin resistance and cardiovascular diseases (CVDs). Although the association between obesity and CVD is a well-established phenomenon, the precise mechanisms remain incompletely understood. This has led to a relative paucity of therapeutic measures...

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Bibliographic Details
Main Authors: Omar Mohammed Amen, Satyajit D. Sarker, Reena Ghildyal, Aditya Arya
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
obesity
cardiac dysfunction
endoplasmic reticulum stress
unfolded protein response
inflammation
insulin resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00977/full

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