Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone

Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone

We reported the first example of organocatalytic Michael addition of unprotected 3-prochiral oxindoles 1 to 1,4-naphthoquinone. Quinidine derivative (DHQD)2PYR was found to be able to catalyze this reaction in up to 83% ee, with moderate to excellent yields. This method could be used for the synthes...

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Bibliographic Details
Main Authors:	Jin-Sheng Yu, Feng Zhou, Yun-Lin Liu, Jian Zhou
Format:	Article
Language:	English
Published:	Beilstein-Institut 2012-08-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	3,3-disubstituted oxindoles Michael addition organocatalysis quaternary stereogenic center unprotected 3-substituted oxindoles
Online Access:	https://doi.org/10.3762/bjoc.8.157

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