Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

Genomic instability, a hallmark of cancer, occurs preferentially at specific genomic regions known as common fragile sites (CFSs). CFSs are evolutionarily conserved and late replicating regions with AT-rich sequences, and CFS instability is correlated with cancer. In the last decade, much progress h...

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Bibliographic Details
Main Authors: Zheng Li, Thomas Liehr, Luciana Gonçalves Quintana, Kristin Mrasek, Jun Zhang, Li Qiu, Ke Ma
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:International Journal of Molecular Sciences
Subjects:
replication
instability
CFS
cancer
FATS
checkpoint
Online Access:http://www.mdpi.com/1422-0067/13/9/11974

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