Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage.MVs were generated in response to tumour necrosis factor-α, from...

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Bibliographic Details
Main Authors: Hefin I. Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V. Norling, Mauro Perretti
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418300525