Microwave-Assisted Method for Simultaneous Extraction and Hydrolysis for Determination of Flavonol Glycosides in <em>Ginkgo </em>Foliage Using Brönsted Acidic Ionic-Liquid [HO<sub>3</sub>S(CH<sub>2</sub>)<sub>4</sub>mim]HSO<sub>4</sub> Aqueous Solutions

• Main Authors: Yuangang Zu, Chunjian Zhao, Xiangdong Meng, Fengjian Yang, Wenjie Wang, Lei Yang, Huanhuan Yao, Xinxuan Du, Lin Zhang
• Format: Article
• Language: English
• Published: MDPI AG 2012-07-01
• Series: International Journal of Molecular Sciences
• Subjects: <em>Ginkgo biloba</em> ionic liquid; [HO<sub>3</sub>S(CH<sub>2</sub>)<sub>4</sub>mim]HSO<sub>4</sub> microwave-assisted extraction; hydrolysis; flavonol glycoside
• Online Access: http://www.mdpi.com/1422-0067/13/7/8775
• ISSN: 1422-0067

The Brönsted acidic ionic-liquid [HO<sub>3</sub>S(CH<sub>2</sub>)<sub>4</sub>mim] HSO<sub>4</sub>, a novel dual catalyst–solvent, has been successfully applied in simultaneous microwave-assisted extraction and hydrolysis for the determination of flavonol glycosides in <em>Ginkgo</em> foliage. The parameters, namely the [HO<sub>3</sub>S(CH<sub>2</sub>)<sub>4</sub>mim]HSO<sub>4</sub> concentration, microwave-irradiation power, microwave-irradiation time, and solid–liquid ratio, were optimized. The optimum conditions were: an amount of 1.5 M [HO<sub>3</sub>S(CH<sub>2</sub>)<sub>4</sub>mim]HSO<sub>4</sub>, a microwave-irradiation power of 120 W, an irradiation time of 15 min, and a solid–liquid ratio of 1:30 g/mL. Compared with traditional methods the proposed approach demonstrates higher efficiency in a shorter operating time, and is an efficient, rapid, and simple sample preparation method.