The Chemical Fluctuation Theorem governing gene expression

The Chemical Fluctuation Theorem governing gene expression

A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise...

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Main Authors: Seong Jun Park, Sanggeun Song, Gil-Suk Yang, Philip M. Kim, Sangwoon Yoon, Ji-Hyun Kim, Jaeyoung Sung
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02737-0
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spelling doaj-453b0f4d9a3147b59f1f6680d93343c02021-05-11T10:28:47ZengNature Publishing GroupNature Communications2041-17232018-01-019111210.1038/s41467-017-02737-0The Chemical Fluctuation Theorem governing gene expressionSeong Jun Park0Sanggeun Song1Gil-Suk Yang2Philip M. Kim3Sangwoon Yoon4Ji-Hyun Kim5Jaeyoung Sung6Creative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang UniversityCreative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang UniversityCreative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang UniversityTerrence Donnelly Center for Cellular and Biomolecular Research, Department of Molecular Genetics and Department of Computer Science, University of TorontoDepartment of Chemistry, Chung-Ang UniversityCreative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang UniversityCreative Research Initiative Center for Chemical Dynamics in Living Cells, Chung-Ang UniversityA unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise on mRNA lifetime variability.https://doi.org/10.1038/s41467-017-02737-0
collection DOAJ
language English
format Article
sources DOAJ
author Seong Jun Park
Sanggeun Song
Gil-Suk Yang
Philip M. Kim
Sangwoon Yoon
Ji-Hyun Kim
Jaeyoung Sung
spellingShingle Seong Jun Park
Sanggeun Song
Gil-Suk Yang
Philip M. Kim
Sangwoon Yoon
Ji-Hyun Kim
Jaeyoung Sung
The Chemical Fluctuation Theorem governing gene expression
Nature Communications
author_facet Seong Jun Park
Sanggeun Song
Gil-Suk Yang
Philip M. Kim
Sangwoon Yoon
Ji-Hyun Kim
Jaeyoung Sung
author_sort Seong Jun Park
title The Chemical Fluctuation Theorem governing gene expression
title_short The Chemical Fluctuation Theorem governing gene expression
title_full The Chemical Fluctuation Theorem governing gene expression
title_fullStr The Chemical Fluctuation Theorem governing gene expression
title_full_unstemmed The Chemical Fluctuation Theorem governing gene expression
title_sort chemical fluctuation theorem governing gene expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise on mRNA lifetime variability.
url https://doi.org/10.1038/s41467-017-02737-0
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