The Chemical Fluctuation Theorem governing gene expression

A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise...

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Bibliographic Details
Main Authors: Seong Jun Park, Sanggeun Song, Gil-Suk Yang, Philip M. Kim, Sangwoon Yoon, Ji-Hyun Kim, Jaeyoung Sung
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02737-0
Description
Summary:A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise on mRNA lifetime variability.
ISSN:2041-1723