The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

Kinesin-14s are commonly considered to be minus end-directed microtubule motor proteins. Here the authors show that KlpA, a fungal kinesin-14 orthologue, relies on its N-terminal nonmotor microtubule-binding tail to achieve context-dependent bidirectional motility.

Bibliographic Details
Main Authors: Andrew R. Popchock, Kuo-Fu Tseng, Pan Wang, P. Andrew Karplus, Xin Xiang, Weihong Qiu
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13999
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spelling doaj-452fe2c9c270404e86830743dc6002c82021-05-11T07:09:33ZengNature Publishing GroupNature Communications2041-17232017-01-01811910.1038/ncomms13999The mitotic kinesin-14 KlpA contains a context-dependent directionality switchAndrew R. Popchock0Kuo-Fu Tseng1Pan Wang2P. Andrew Karplus3Xin Xiang4Weihong Qiu5Department of Biochemistry and Biophysics, Oregon State UniversityDepartment of Physics, Oregon State UniversityDepartment of Physics, Oregon State UniversityDepartment of Biochemistry and Biophysics, Oregon State UniversityDepartment of Biochemistry and Molecular Biology, The Uniformed Services University of the Health SciencesDepartment of Biochemistry and Biophysics, Oregon State UniversityKinesin-14s are commonly considered to be minus end-directed microtubule motor proteins. Here the authors show that KlpA, a fungal kinesin-14 orthologue, relies on its N-terminal nonmotor microtubule-binding tail to achieve context-dependent bidirectional motility.https://doi.org/10.1038/ncomms13999
collection DOAJ
language English
format Article
sources DOAJ
author Andrew R. Popchock
Kuo-Fu Tseng
Pan Wang
P. Andrew Karplus
Xin Xiang
Weihong Qiu
spellingShingle Andrew R. Popchock
Kuo-Fu Tseng
Pan Wang
P. Andrew Karplus
Xin Xiang
Weihong Qiu
The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
Nature Communications
author_facet Andrew R. Popchock
Kuo-Fu Tseng
Pan Wang
P. Andrew Karplus
Xin Xiang
Weihong Qiu
author_sort Andrew R. Popchock
title The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
title_short The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
title_full The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
title_fullStr The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
title_full_unstemmed The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
title_sort mitotic kinesin-14 klpa contains a context-dependent directionality switch
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-01-01
description Kinesin-14s are commonly considered to be minus end-directed microtubule motor proteins. Here the authors show that KlpA, a fungal kinesin-14 orthologue, relies on its N-terminal nonmotor microtubule-binding tail to achieve context-dependent bidirectional motility.
url https://doi.org/10.1038/ncomms13999
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