Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase

Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase

Gastric cancer (GC) is one of the most common cancers worldwide. In the clinical setting, the identification of HER2 overexpression in GC was a significant finding, as trastuzumab, an anti-HER2 drug, provides a survival advantage to HER2-positive GC patients. In HER2-postive GC, the dysregulation of...

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Bibliographic Details
Main Authors: Yoshihisa Tokumaru, Toshihiro Tajirika, Nobuhiko Sugito, Yuki Kuranaga, Haruka Shinohara, Takuya Tsujino, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
miR-143
HER2-positive gastric cancer
KRAS
DDX6
Online Access:https://www.mdpi.com/1422-0067/20/7/1697

Internet

https://www.mdpi.com/1422-0067/20/7/1697

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