SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment

Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Since ERα+ luminal cells express stem cell antigen-1 (SCA-1), we...

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Bibliographic Details
Main Authors: Genevieve V. Dall, Jessica L. Vieusseux, Kenneth S. Korach, Yukitomo Arao, Sylvia C. Hewitt, Katherine J. Hamilton, Elaine Dzierzak, Wah Chin Boon, Evan R. Simpson, Robert G. Ramsay, Torsten Stein, Joanne S. Morris, Robin L. Anderson, Gail P. Risbridger, Kara L. Britt
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Stem Cell Reports
Subjects:
estrogen
mammary stem cells
Sca-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116303125

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