Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease

Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease

The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 μg) significantly decreases the total number of leukocytes and erythrocyt...

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Bibliographic Details
Main Authors: Hritcu L., Stefan M., Misaila Costica, Ciobica A., Dumitru Gabriela
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2011-01-01
Series:Archives of Biological Sciences
Subjects:
6-hydroxydopamine
lipopolysaccharide
leukocyte
erythrocyte indexes
phagocytosis
proliferative response of T lymphocytes
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641101099H.pdf
Description
Summary:The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 μg) significantly decreases the total number of leukocytes and erythrocytes, as well as the hemoglobin level in the 6-OHDAlesioned rats. In addition, LPS administration was also associated with an increase, relative to control, in the erythrocyte indexes and the phagocytosis by neutrophils, and in blastic transformation of T lymphocytes. The obtained data indicated that LPS exposure might represent a risk factor for the development of the immunological changes associated with Parkinson’s disease.
ISSN:0354-4664

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