Varfarin v terapii antifosfolipidnogo sindroma

• Main Authors: T M Reshetnyak, L V Kondrat'eva, I B Shtivel'band, E L Nasonov
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2008-04-01
• Series: Современная ревматология
• Online Access: https://mrj.ima-press.net/mrj/article/view/154
• ISSN: 1996-7012; 2310-158X

Opisany farmakokinetika, farmakodinamika i monitoring terapii varfarinom. Rassmotreny voprosy povyshennoy chuvstvitel'nosti chasti patsientov k varfarinu, a imenno assotsiatsiya izbytochnoy gipokoagulyatsii s mutatsiyami v gene tsitokhroma R450 CYP2C9*2 I CYP2C9*3. Summirovany dannye literatury o primenenii varfarina u bol'nykh s antifosfolipidnym sindromom (AFS). Predstavleny dannye, kasayushchiesya intensivnosti antikoagulyantnoy terapii pri AFS. Privedeny rekomendatsii i kommentarii, osnovannye na sobstvennom opyte vedeniya bol'nykh s AFS.