The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

Here we describe a novel bifunctional fusion protein, designated N-809. This molecule comprises the IL-15/IL15Rα superagonist complex containing the Fc-domain of IgG1 (N-803, formerly designated as ALT-803) fused to two single chain anti-PD-L1 domains. The fully human IgG1 portion of the N-809 molec...

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Bibliographic Details
Main Authors: Caroline Jochems, Sarah R. Tritsch, Karin M. Knudson, Sofia R. Gameiro, Claire Smalley Rumfield, Samuel T. Pellom, Y. Maurice Morillon, Robby Newman, Warren Marcus, Christopher Szeto, Shahrooz Rabizadeh, Hing C. Wong, Patrick Soon-Shiong, Jeffrey Schlom
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:OncoImmunology
Subjects:
alt-803
n-803
il-15
n-809
anti-pd-l1
immunotherapy
checkpoint inhibitor
cytokine
carcinoma
adcc
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1532764

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