Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin

Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin

Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin. Here authors use single-molecule imaging, X-ray crystallography and simulations on chitinase A (SmChiA) and show that Brownian motion along the single chitin chain is rectified forward by substrate-ass...

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Main Authors: Akihiko Nakamura, Kei-ichi Okazaki, Tadaomi Furuta, Minoru Sakurai, Ryota Iino
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06362-3
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spelling doaj-44bbc30a869946569170e33c852072482021-05-11T09:59:48ZengNature Publishing GroupNature Communications2041-17232018-09-019111210.1038/s41467-018-06362-3Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitinAkihiko Nakamura0Kei-ichi Okazaki1Tadaomi Furuta2Minoru Sakurai3Ryota Iino4Institute for Molecular Science, National Institutes of Natural SciencesInstitute for Molecular Science, National Institutes of Natural SciencesCenter for Biological Resources and Informatics, Tokyo Institute of TechnologyCenter for Biological Resources and Informatics, Tokyo Institute of TechnologyInstitute for Molecular Science, National Institutes of Natural SciencesProcessive chitinase is a linear molecular motor which moves on the surface of crystalline chitin. Here authors use single-molecule imaging, X-ray crystallography and simulations on chitinase A (SmChiA) and show that Brownian motion along the single chitin chain is rectified forward by substrate-assisted catalysis.https://doi.org/10.1038/s41467-018-06362-3
collection DOAJ
language English
format Article
sources DOAJ
author Akihiko Nakamura
Kei-ichi Okazaki
Tadaomi Furuta
Minoru Sakurai
Ryota Iino
spellingShingle Akihiko Nakamura
Kei-ichi Okazaki
Tadaomi Furuta
Minoru Sakurai
Ryota Iino
Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
Nature Communications
author_facet Akihiko Nakamura
Kei-ichi Okazaki
Tadaomi Furuta
Minoru Sakurai
Ryota Iino
author_sort Akihiko Nakamura
title Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
title_short Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
title_full Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
title_fullStr Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
title_full_unstemmed Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
title_sort processive chitinase is brownian monorail operated by fast catalysis after peeling rail from crystalline chitin
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin. Here authors use single-molecule imaging, X-ray crystallography and simulations on chitinase A (SmChiA) and show that Brownian motion along the single chitin chain is rectified forward by substrate-assisted catalysis.
url https://doi.org/10.1038/s41467-018-06362-3
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AT keiichiokazaki processivechitinaseisbrownianmonorailoperatedbyfastcatalysisafterpeelingrailfromcrystallinechitin
AT tadaomifuruta processivechitinaseisbrownianmonorailoperatedbyfastcatalysisafterpeelingrailfromcrystallinechitin
AT minorusakurai processivechitinaseisbrownianmonorailoperatedbyfastcatalysisafterpeelingrailfromcrystallinechitin
AT ryotaiino processivechitinaseisbrownianmonorailoperatedbyfastcatalysisafterpeelingrailfromcrystallinechitin
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