Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts
The impact of integrins oscillation on intracellular calcium in conditions of native actin microfilaments network and under depolymerization was studied on the model of α(2)β(1)-integrins forced cyclic fluctuations with the use of integrin-specific magnetic microparticles, that were exposed to magne...
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| Language: | Russian |
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Academic Publishing House Researcher
2013-01-01
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| Series: | Evropejskij Issledovatelʹ |
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| Online Access: | http://www.erjournal.ru/pdf.html?n=1361902593.pdf |
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doaj-44b9c287570948bc9b0d0f47eddbfde52020-11-24T20:45:39ZrusAcademic Publishing House ResearcherEvropejskij Issledovatelʹ2219-82292224-01362013-01-01402-1226232Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of FibroblastsEkaterina V. KotYurij G. KotMaria A. GrytsenkoLiubov V. AltukhovaYevgen E. PerskyThe impact of integrins oscillation on intracellular calcium in conditions of native actin microfilaments network and under depolymerization was studied on the model of α(2)β(1)-integrins forced cyclic fluctuations with the use of integrin-specific magnetic microparticles, that were exposed to magnetic field after being cell-attached. It proved that α(2)β(1)-integrins are involved in the response of fibroblasts to mechanical deformation, activating depot-dependent calcium efflux in cytoplasm. Cytoskeletal actin microfilaments are also involved in the response via these receptors, which integrity is essential for normal functioning of the depot-dependent mechanism of Ca2+ efflux in cytoplasm of deformable fibroblastshttp://www.erjournal.ru/pdf.html?n=1361902593.pdfmechanical deformationfibroblastsintegrinsactincalcium |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
Ekaterina V. Kot Yurij G. Kot Maria A. Grytsenko Liubov V. Altukhova Yevgen E. Persky |
| spellingShingle |
Ekaterina V. Kot Yurij G. Kot Maria A. Grytsenko Liubov V. Altukhova Yevgen E. Persky Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts Evropejskij Issledovatelʹ mechanical deformation fibroblasts integrins actin calcium |
| author_facet |
Ekaterina V. Kot Yurij G. Kot Maria A. Grytsenko Liubov V. Altukhova Yevgen E. Persky |
| author_sort |
Ekaterina V. Kot |
| title |
Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts |
| title_short |
Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts |
| title_full |
Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts |
| title_fullStr |
Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts |
| title_full_unstemmed |
Relation between Integrins Forced Oscillation, Degree of Actin Cytoskeleton Polymerization and Content of Free Ca2+ of Fibroblasts |
| title_sort |
relation between integrins forced oscillation, degree of actin cytoskeleton polymerization and content of free ca2+ of fibroblasts |
| publisher |
Academic Publishing House Researcher |
| series |
Evropejskij Issledovatelʹ |
| issn |
2219-8229 2224-0136 |
| publishDate |
2013-01-01 |
| description |
The impact of integrins oscillation on intracellular calcium in conditions of native actin microfilaments network and under depolymerization was studied on the model of α(2)β(1)-integrins forced cyclic fluctuations with the use of integrin-specific magnetic microparticles, that were exposed to magnetic field after being cell-attached. It proved that α(2)β(1)-integrins are involved in the response of fibroblasts to mechanical deformation, activating depot-dependent calcium efflux in cytoplasm. Cytoskeletal actin microfilaments are also involved in the response via these receptors, which integrity is essential for normal functioning of the depot-dependent mechanism of Ca2+ efflux in cytoplasm of deformable fibroblasts |
| topic |
mechanical deformation fibroblasts integrins actin calcium |
| url |
http://www.erjournal.ru/pdf.html?n=1361902593.pdf |
| work_keys_str_mv |
AT ekaterinavkot relationbetweenintegrinsforcedoscillationdegreeofactincytoskeletonpolymerizationandcontentoffreeca2offibroblasts AT yurijgkot relationbetweenintegrinsforcedoscillationdegreeofactincytoskeletonpolymerizationandcontentoffreeca2offibroblasts AT mariaagrytsenko relationbetweenintegrinsforcedoscillationdegreeofactincytoskeletonpolymerizationandcontentoffreeca2offibroblasts AT liubovvaltukhova relationbetweenintegrinsforcedoscillationdegreeofactincytoskeletonpolymerizationandcontentoffreeca2offibroblasts AT yevgenepersky relationbetweenintegrinsforcedoscillationdegreeofactincytoskeletonpolymerizationandcontentoffreeca2offibroblasts |
| _version_ |
1716814248382824448 |