Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654.
In fed rat livers perfused with [1-14C]oleic acid, Ro 22-0654 (4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride), an inhibitor of fatty acid synthesis, activated ketogenesis and decreased the secretion of triglyceride in very low density lipoproteins (VLDL). Ro 22-0654 was witho...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1985-10-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752034267X |