Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behaviour...

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Main Authors: Ki Kim, Xin Wang, Emeline Ragonnaud, Monica Bodogai, Tomer Illouz, Marisa DeLuca, Ross A. McDevitt, Fedor Gusev, Eitan Okun, Evgeny Rogaev, Arya Biragyn
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22479-4
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spelling doaj-44ad602eff5f455e94eb988bbdc2dcdc2021-04-18T11:12:54ZengNature Publishing GroupNature Communications2041-17232021-04-0112111110.1038/s41467-021-22479-4Therapeutic B-cell depletion reverses progression of Alzheimer’s diseaseKi Kim0Xin Wang1Emeline Ragonnaud2Monica Bodogai3Tomer Illouz4Marisa DeLuca5Ross A. McDevitt6Fedor Gusev7Eitan Okun8Evgeny Rogaev9Arya Biragyn10Immunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingThe Mina and Everard Goodman faculty of Life SciencesImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingMouse Phenotyping Unit, Comparative Medicine Section, National Institute on AgingDepartment of Genomics and Human Genetics, Institute of General Genetics, Russian Academy of SciencesThe Mina and Everard Goodman faculty of Life SciencesDepartment of Genomics and Human Genetics, Institute of General Genetics, Russian Academy of SciencesImmunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on AgingAlzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.https://doi.org/10.1038/s41467-021-22479-4
collection DOAJ
language English
format Article
sources DOAJ
author Ki Kim
Xin Wang
Emeline Ragonnaud
Monica Bodogai
Tomer Illouz
Marisa DeLuca
Ross A. McDevitt
Fedor Gusev
Eitan Okun
Evgeny Rogaev
Arya Biragyn
spellingShingle Ki Kim
Xin Wang
Emeline Ragonnaud
Monica Bodogai
Tomer Illouz
Marisa DeLuca
Ross A. McDevitt
Fedor Gusev
Eitan Okun
Evgeny Rogaev
Arya Biragyn
Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
Nature Communications
author_facet Ki Kim
Xin Wang
Emeline Ragonnaud
Monica Bodogai
Tomer Illouz
Marisa DeLuca
Ross A. McDevitt
Fedor Gusev
Eitan Okun
Evgeny Rogaev
Arya Biragyn
author_sort Ki Kim
title Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_short Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_full Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_fullStr Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_full_unstemmed Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
title_sort therapeutic b-cell depletion reverses progression of alzheimer’s disease
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-04-01
description Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.
url https://doi.org/10.1038/s41467-021-22479-4
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AT xinwang therapeuticbcelldepletionreversesprogressionofalzheimersdisease
AT emelineragonnaud therapeuticbcelldepletionreversesprogressionofalzheimersdisease
AT monicabodogai therapeuticbcelldepletionreversesprogressionofalzheimersdisease
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