Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behaviour...
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Bibliographic Details
| Main Authors: |
Ki Kim,
Xin Wang,
Emeline Ragonnaud,
Monica Bodogai,
Tomer Illouz,
Marisa DeLuca,
Ross A. McDevitt,
Fedor Gusev,
Eitan Okun,
Evgeny Rogaev,
Arya Biragyn |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22479-4
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