Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors

Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors

In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones was designed and synthesized with the goal of improving the biological activity as 17b-hydroxysteroid dehydrogenase type 2 inhibitors of the corresponding amidothiophene der...

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Bibliographic Details
Main Authors: Rolf W. Hartmann, Enrico Perspicace, Sandrine Marchais-Oberwinkler
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Molecules
Subjects:
thieno[3,2-d]pyrimidinones
thieno[3,2-d]pyrimidines
quinazolinones
conformationally restricted analogues
enzyme inhibitors
17b-hydroxysteroid dehydrogenase type 2
osteoporosis
Online Access:http://www.mdpi.com/1420-3049/18/4/4487

Internet

http://www.mdpi.com/1420-3049/18/4/4487

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