Effect of deep anesthesia on blood gas and immune function in patients undergoing laparoscopic radical gastrectomy for gastric cancer

• Main Authors: Zhen Wang, Xiao-Fan Li, Hui Wang, Zhi-Jun Mao, Tong Xue, Rui Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-07-01
• Series: Journal of Hainan Medical University
• Subjects: Deep anesthesia; Laparoscopic radical gastrectomy; Blood gas; Immune function
• Online Access: http://www.hnykdxxb.com/PDF/201614/33.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the effects of deep anesthesia on blood gas and immune function in patients undergoing laparoscopic radical gastrectomy for gastric cancer. Methods: A total of 84 gastric cancer patients in our hospital were randomly divided into observation group (42 cases) and control group (42 cases). Patients in observation group were treated by deep anesthesia, while the control group was treated with shallow anesthesia. The blood gas was observed and compared before and after CO2 pneumoperitoneum, and the immune function was observed and compared before anesthesia, after operation and 72 h post-operation. Results: The PaCO2 and pH level of patients in the two groups had no significant difference before pneumoperitoneum; Compared with before pneumoperitoneum, no obvious blood gas change was observed in the observation group, the difference had no statistically significant; Blood gas level of control group was significantly higher than that of before pneumoperitoneum , the difference was statistically significant, pH (7.26 依 0.07) was statistically decreased; After pneumoperitoneum, the level of PaCO2 and pH was significantly different in both groups , the difference was statistically significant. Indexes of the patients in the observation and control group of CD3+, CD4+, CD4+/CD8+, NK level had no significant difference before anesthesia, the difference was not statistically significant; The immunology index of CD3+, CD4+, CD4+/ CD8+ and NK cell levels of the postoperative patients in both groups were significantly lower than before anesthesia, and the differences were statistically significant, but each index in the observation group decreased significantly less than that of the control group, the difference was statistically significant; The immunological indexes can be restored to before anesthesia postoperative 72 h with two groups, and had no significant difference. Conclusion: The blood gas analysis index was stable and the immune function was suppressed in patients with deep anesthesia.