Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity

Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity

The mechanisms by which obesity may alter immune responses to pathogens are poorly understood. The present study assessed whether the intrinsic responsiveness of resident macrophages to bacterial lipopolysaccharide (LPS) is reprogrammed in high-fat diet (HFD)-induced obesity. Macrophages from adipos...

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Bibliographic Details
Main Authors: Evilin N. Komegae, Monique T. Fonseca, Sanseray da Silveira Cruz-Machado, Walter M. Turato, Luciano R. Filgueiras, Regina P. Markus, Alexandre A. Steiner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
obese
fat
diet
immune
inflammation
host defense
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01496/full

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