Chemical Constituents from Croton Species and Their Biological Activities

The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018...

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Main Authors:	Wen-Hui Xu, Wei-Yi Liu, Qian Liang
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Molecules
Subjects:	Croton species phytochemistry biological activities diterpenoids cytotoxicity
Online Access:	http://www.mdpi.com/1420-3049/23/9/2333

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spelling	doaj-4486404c590f4a139b6803285505c5032020-11-25T02:17:14ZengMDPI AGMolecules1420-30492018-09-01239233310.3390/molecules23092333molecules23092333Chemical Constituents from Croton Species and Their Biological ActivitiesWen-Hui Xu0Wei-Yi Liu1Qian Liang2Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, ChinaKey Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, ChinaKey Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, ChinaThe genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.http://www.mdpi.com/1420-3049/23/9/2333Croton speciesphytochemistrybiological activitiesditerpenoidscytotoxicity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wen-Hui Xu Wei-Yi Liu Qian Liang
spellingShingle	Wen-Hui Xu Wei-Yi Liu Qian Liang Chemical Constituents from Croton Species and Their Biological Activities Molecules Croton species phytochemistry biological activities diterpenoids cytotoxicity
author_facet	Wen-Hui Xu Wei-Yi Liu Qian Liang
author_sort	Wen-Hui Xu
title	Chemical Constituents from Croton Species and Their Biological Activities
title_short	Chemical Constituents from Croton Species and Their Biological Activities
title_full	Chemical Constituents from Croton Species and Their Biological Activities
title_fullStr	Chemical Constituents from Croton Species and Their Biological Activities
title_full_unstemmed	Chemical Constituents from Croton Species and Their Biological Activities
title_sort	chemical constituents from croton species and their biological activities
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2018-09-01
description	The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.
topic	Croton species phytochemistry biological activities diterpenoids cytotoxicity
url	http://www.mdpi.com/1420-3049/23/9/2333
work_keys_str_mv	AT wenhuixu chemicalconstituentsfromcrotonspeciesandtheirbiologicalactivities AT weiyiliu chemicalconstituentsfromcrotonspeciesandtheirbiologicalactivities AT qianliang chemicalconstituentsfromcrotonspeciesandtheirbiologicalactivities
_version_	1724887465094807552

Chemical Constituents from Croton Species and Their Biological Activities

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