Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2

A series of 2-(1<i>H</i>-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, <b>4a–m,</b> were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds. Synthesis of the target 1,3,4-oxadia...

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Bibliographic Details
Main Authors:	Rania Hamdy, Samia A. Elseginy, Noha I. Ziedan, Mohamed El-Sadek, Elsaid Lashin, Arwyn T. Jones, Andrew D. Westwell
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	International Journal of Molecular Sciences
Subjects:	oxadiazole indole aromatic heterocycle anticancer Bcl-2 inhibitor chemical synthesis
Online Access:	https://www.mdpi.com/1422-0067/21/23/8980

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