8-O-Acetyl Shanzhiside Methylester From Lamiophlomis Rotata Reduces Neuropathic Pain by Inhibiting the ERK/TNF-α Pathway in Spinal Astrocytes

8-O-Acetyl Shanzhiside Methylester From Lamiophlomis Rotata Reduces Neuropathic Pain by Inhibiting the ERK/TNF-α Pathway in Spinal Astrocytes

Lamiophlomis rotata (L. rotata; Benth.) Kudo is an effective traditional herb in the clinical treatment of chronic pain syndromes in China. 8-O-acetyl shanzhiside methylester (8-OaS), a chief component in L. rotata, possesses potent immunosuppressive activities and favorable analgesic effects. This...

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Bibliographic Details
Main Authors: Wei Zhang, Yang Bai, Yu Qiao, Jian Wang, Meng-Ying Li, Jing-Wen Wang, Na Jia, Tao Chen, Yun-Qing Li, Ai-Dong Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuropathic pain
8-O-acetyl shanzhiside methylester
ERK
SNL
spinal dorsal horn
astrocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00054/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00054/full

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