Aerosols of synthetic amorphous silica do not induce fibrosis in lungs after inhalation: Pathology working group review of histopathological specimens from a subchronic 13-week inhalation toxicity study in rats

Aerosols of synthetic amorphous silica do not induce fibrosis in lungs after inhalation: Pathology working group review of histopathological specimens from a subchronic 13-week inhalation toxicity study in rats

In a subchronic (13-week) inhalation toxicity study with a terminal sacrifice (after 13 weeks inhalation) and several recovery period sacrifices (13, 26, 39, and 52 weeks), the effects of AEROSIL ® 200 (pyrogenic synthetic amorphous silica (SAS)), AEROSIL ® R 974 (surface-treated pyrogenic SAS), and...

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Bibliographic Details
Main Authors: Klaus Weber, Axel Bosch, Mario Bühler, Chirukandath Gopinath, Jerry F Hardisty, Nils Krueger, Ernest E McConnell, Günter Oberdörster
Format: Article
Language:English
Published: SAGE Publishing 2018-11-01
Series:Toxicology Research and Application
Online Access:https://doi.org/10.1177/2397847318805273

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