Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.

Bibliographic Details
Main Authors: Federica Verginelli, Alberto Pisacane, Gennaro Gambardella, Antonio D’Ambrosio, Ermes Candiello, Marco Ferrio, Mara Panero, Laura Casorzo, Silvia Benvenuti, Eliano Cascardi, Rebecca Senetta, Elena Geuna, Andrea Ballabio, Filippo Montemurro, Anna Sapino, Paolo M. Comoglio, Carla Boccaccio
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22643-w
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spelling doaj-4477922c33134d2989690669cbc5e8c02021-05-09T11:12:13ZengNature Publishing GroupNature Communications2041-17232021-05-0112111610.1038/s41467-021-22643-wCancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibitionFederica Verginelli0Alberto Pisacane1Gennaro Gambardella2Antonio D’Ambrosio3Ermes Candiello4Marco Ferrio5Mara Panero6Laura Casorzo7Silvia Benvenuti8Eliano Cascardi9Rebecca Senetta10Elena Geuna11Andrea Ballabio12Filippo Montemurro13Anna Sapino14Paolo M. Comoglio15Carla Boccaccio16Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSTelethon Institute of Genetics and Medicine (TIGEM)Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCSLaboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCSLaboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSLaboratory of Exploratory Research and Molecular Cancer Therapy, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSMultidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCSTelethon Institute of Genetics and Medicine (TIGEM)Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCSUnit of Pathology, Candiolo Cancer Institute, FPO-IRCCSLaboratory of Exploratory Research and Molecular Cancer Therapy, Candiolo Cancer Institute, FPO-IRCCSLaboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCSCancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.https://doi.org/10.1038/s41467-021-22643-w
collection DOAJ
language English
format Article
sources DOAJ
author Federica Verginelli
Alberto Pisacane
Gennaro Gambardella
Antonio D’Ambrosio
Ermes Candiello
Marco Ferrio
Mara Panero
Laura Casorzo
Silvia Benvenuti
Eliano Cascardi
Rebecca Senetta
Elena Geuna
Andrea Ballabio
Filippo Montemurro
Anna Sapino
Paolo M. Comoglio
Carla Boccaccio
spellingShingle Federica Verginelli
Alberto Pisacane
Gennaro Gambardella
Antonio D’Ambrosio
Ermes Candiello
Marco Ferrio
Mara Panero
Laura Casorzo
Silvia Benvenuti
Eliano Cascardi
Rebecca Senetta
Elena Geuna
Andrea Ballabio
Filippo Montemurro
Anna Sapino
Paolo M. Comoglio
Carla Boccaccio
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
Nature Communications
author_facet Federica Verginelli
Alberto Pisacane
Gennaro Gambardella
Antonio D’Ambrosio
Ermes Candiello
Marco Ferrio
Mara Panero
Laura Casorzo
Silvia Benvenuti
Eliano Cascardi
Rebecca Senetta
Elena Geuna
Andrea Ballabio
Filippo Montemurro
Anna Sapino
Paolo M. Comoglio
Carla Boccaccio
author_sort Federica Verginelli
title Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
title_short Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
title_full Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
title_fullStr Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
title_full_unstemmed Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
title_sort cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to mek inhibition
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.
url https://doi.org/10.1038/s41467-021-22643-w
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