The Notch ligand Jagged1 as a target for anti-tumour therapy

The Notch ligand Jagged1 as a target for anti-tumour therapy

The Notch pathway is increasingly attracting attention as a source of therapeutic targets for cancer. Ligand-induced Notch signalling has been implicated in various aspects of cancer biology; as a consequence pan-Notch inhibitors and therapeutic antibodies targeting one or more of the Notch receptor...

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Bibliographic Details
Main Authors: Demin eLi, Massimo eMasiero, Alison H Banham, Adrian L Harris
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Oncology
Subjects:
Angiogenesis
cancer stem cells
cancer therapy
Jagged1
Notch pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00254/full

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