Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

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Bibliographic Details
Main Authors: Alexander V. Grishin, Nikita V. Shestak, Natalia V. Lavrova, Alexander M. Lyashchuk, Liubov I. Popova, Natalia V. Strukova, Maria S. Generalova, Anna V. Ryazanova, Nikita B. Polyakov, Zoya M. Galushkina, Lyubov A. Soboleva, Irina S. Boksha, Anna S. Karyagina, Vladimir G. Lunin
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
antibiotic resistance
endolysin
lysin
lysostaphin
albumin-binding domain
pharmacokinetics
pharmacodynamics
Online Access:https://www.mdpi.com/1420-3049/24/16/2892

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