Nanoparticle-based drug delivery systems: promising approaches against infections

• Main Authors: Shweta Ranghar, Parul Sirohi, Pritam Verma, Vishnu Agarwal
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Paraná (Tecpar) 2014-04-01
• Series: Brazilian Archives of Biology and Technology
• Subjects: Antimicrobial Nanoparticles; Drug Resistance; Drug Delivery System; Infection; Metal and Metal Oxide
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200008&lng=en&tlng=en

Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections.