Xanthan/chondroitin sulfate hydrogels as carrier for drug delivery applications
Preparation, characterization and in vitro release studies of codeine from xanthan/chondroitin sulfate (X/CS) hydrogels prepared through a crosslinking technique are reported. Swelling and drug delivery studies were conducted in phosphate buffer solution (pH=7.4) which simulates the pH of the intest...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Alexandru Ioan Cuza" University of Iași
2010-06-01
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| Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
| Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/882 |
| Summary: | Preparation, characterization and in vitro release studies of codeine from xanthan/chondroitin sulfate (X/CS) hydrogels prepared through a crosslinking technique are reported. Swelling and drug delivery studies were conducted in phosphate buffer solution (pH=7.4) which simulates the pH of the intestinal fluid, at 37 °C. The in vitro release test revealed that the percentage of codeine released in phosphate buffer solution increases with increasing the amount of chondroitin sulfate in the composition of hydrogels. The drug release behaviour of the hydrogels loaded with codeine fitted well with case II transport mechanism for all formulations. The biocompatibility testing was made by hemolisys (plasma hemoglobin) technique. |
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| ISSN: | 1582-3571 |