MicroRNA-155 and Its Role in Malignant Hematopoiesis

MicroRNA-155 and Its Role in Malignant Hematopoiesis

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MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and th...

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Main Author: Prajnya Ranganath
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Biomarker Insights
Online Access:https://doi.org/10.4137/BMI.S27676
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spelling doaj-444d3978d30848a886681dc22b0ec32d2020-11-25T03:39:23ZengSAGE PublishingBiomarker Insights1177-27192015-01-011010.4137/BMI.S27676MicroRNA-155 and Its Role in Malignant HematopoiesisPrajnya Ranganath0Diagnostics Division, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India.MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and the type of malignancy. In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. This review focuses on the molecular interactions of miR-155, its oncogenic mechanisms, and its potential as an effective therapeutic target for the associated malignancies.https://doi.org/10.4137/BMI.S27676
collection DOAJ
language English
format Article
sources DOAJ
author Prajnya Ranganath
spellingShingle Prajnya Ranganath
MicroRNA-155 and Its Role in Malignant Hematopoiesis
Biomarker Insights
author_facet Prajnya Ranganath
author_sort Prajnya Ranganath
title MicroRNA-155 and Its Role in Malignant Hematopoiesis
title_short MicroRNA-155 and Its Role in Malignant Hematopoiesis
title_full MicroRNA-155 and Its Role in Malignant Hematopoiesis
title_fullStr MicroRNA-155 and Its Role in Malignant Hematopoiesis
title_full_unstemmed MicroRNA-155 and Its Role in Malignant Hematopoiesis
title_sort microrna-155 and its role in malignant hematopoiesis
publisher SAGE Publishing
series Biomarker Insights
issn 1177-2719
publishDate 2015-01-01
description MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and the type of malignancy. In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. This review focuses on the molecular interactions of miR-155, its oncogenic mechanisms, and its potential as an effective therapeutic target for the associated malignancies.
url https://doi.org/10.4137/BMI.S27676
work_keys_str_mv AT prajnyaranganath microrna155anditsroleinmalignanthematopoiesis
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