YAP, ΔNp63, and β-Catenin Signaling Pathways Are Involved in the Modulation of Corneal Epithelial Stem Cell Phenotype Induced by Substrate Stiffness

YAP, ΔNp63, and β-Catenin Signaling Pathways Are Involved in the Modulation of Corneal Epithelial Stem Cell Phenotype Induced by Substrate Stiffness

Recent studies have established that the phenotype of epithelial stem cells residing in the corneal periphery (the limbus) depends on this niche’s distinct biomechanical properties. However, the signaling pathways underlying this dependency are still poorly understood. To address this issu...

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Bibliographic Details
Main Authors: Ricardo M. Gouveia, Flora Vajda, Jason A. Wibowo, Francisco Figueiredo, Che J. Connon
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
tissue stiffness
limbal epithelial stem cells
mechanotransduction
epithelial stratification
β-Catenin signaling
fibrosis
Online Access:https://www.mdpi.com/2073-4409/8/4/347

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