A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation.

A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation.

BACKGROUND:The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a and its receptor on neutrophils, CD88, play a central role. The functional role of the second receptor of C5a, C5L2, remains unclear. In the c...

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Bibliographic Details
Main Authors: Jian Hao, Chen Wang, Jun Yuan, Min Chen, Ming-Hui Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3681967?pdf=render

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