A mechanism for CO regulation of ion channels

A mechanism for CO regulation of ion channels

Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor...

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Bibliographic Details
Main Authors: Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey, Emma Raven
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03291-z

Internet

https://doi.org/10.1038/s41467-018-03291-z

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