A mechanism for CO regulation of ion channels
Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor...
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Bibliographic Details
| Main Authors: |
Sofia M. Kapetanaki,
Mark J. Burton,
Jaswir Basran,
Chiasa Uragami,
Peter C. E. Moody,
John S. Mitcheson,
Ralf Schmid,
Noel W. Davies,
Pierre Dorlet,
Marten H. Vos,
Nina M. Storey,
Emma Raven |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03291-z
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