Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia

Pulmonary hypertension (PH) has been described in myeloproliferative disorders; monoclonal plasma cell disorder such as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome; and plasma cell dyscrasias such as multiple myeloma and amyloidosis. We describe 4 c...

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Main Authors:	Indranee Rajapreyar, MD, Joanna Joly, MD, Jose Tallaj, MD, Salpy V. Pamboukian, MD, Ayman Haj Assad, MD, Carrie Lenneman, MD, Silvio Litovsky, MD, Arka Chatterjee, MD, Charles Hoopes, MD, Andrew Lenneman, MD
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2542454820301879

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spelling	doaj-443b37dc0072434aae2a5f5b55f126b92021-02-27T04:39:40ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482021-02-0151210218Pulmonary Vascular Disease Due to Plasma Cell DyscrasiaIndranee Rajapreyar, MD0Joanna Joly, MD1Jose Tallaj, MD2Salpy V. Pamboukian, MD3Ayman Haj Assad, MD4Carrie Lenneman, MD5Silvio Litovsky, MD6Arka Chatterjee, MD7Charles Hoopes, MD8Andrew Lenneman, MD9Division of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, Birmingham; Correspondence: Address to Indranee Rajapreyar, MD, Division of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, 1911 University Blvd, THT 311, Birmingham, AL 35233.Division of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular disease, University of Alabama at Birmingham, BirminghamDepartment of Pathology, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular disease, University of Alabama at Birmingham, BirminghamDivision of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, BirminghamDivision of Cardiovascular Disease, Section of Advanced Heart Failure and Transplantation, University of Alabama at Birmingham, BirminghamPulmonary hypertension (PH) has been described in myeloproliferative disorders; monoclonal plasma cell disorder such as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome; and plasma cell dyscrasias such as multiple myeloma and amyloidosis. We describe 4 cases of PH likely due to pulmonary vascular involvement and myocardial deposition from light chain deposition disease, amyloidosis, and multiple myeloma. On the basis of our clinical experience and literature review, we propose screening for plasma cell dyscrasia in patients with heart failure with preserved ejection fraction, unexplained PH, and hematological abnormalities. We also recommend inclusion of cardiopulmonary screening in patients with monoclonal gammopathy of undetermined significance.http://www.sciencedirect.com/science/article/pii/S2542454820301879
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Indranee Rajapreyar, MD Joanna Joly, MD Jose Tallaj, MD Salpy V. Pamboukian, MD Ayman Haj Assad, MD Carrie Lenneman, MD Silvio Litovsky, MD Arka Chatterjee, MD Charles Hoopes, MD Andrew Lenneman, MD
spellingShingle	Indranee Rajapreyar, MD Joanna Joly, MD Jose Tallaj, MD Salpy V. Pamboukian, MD Ayman Haj Assad, MD Carrie Lenneman, MD Silvio Litovsky, MD Arka Chatterjee, MD Charles Hoopes, MD Andrew Lenneman, MD Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia Mayo Clinic Proceedings: Innovations, Quality & Outcomes
author_facet	Indranee Rajapreyar, MD Joanna Joly, MD Jose Tallaj, MD Salpy V. Pamboukian, MD Ayman Haj Assad, MD Carrie Lenneman, MD Silvio Litovsky, MD Arka Chatterjee, MD Charles Hoopes, MD Andrew Lenneman, MD
author_sort	Indranee Rajapreyar, MD
title	Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia
title_short	Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia
title_full	Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia
title_fullStr	Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia
title_full_unstemmed	Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia
title_sort	pulmonary vascular disease due to plasma cell dyscrasia
publisher	Elsevier
series	Mayo Clinic Proceedings: Innovations, Quality & Outcomes
issn	2542-4548
publishDate	2021-02-01
description	Pulmonary hypertension (PH) has been described in myeloproliferative disorders; monoclonal plasma cell disorder such as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome; and plasma cell dyscrasias such as multiple myeloma and amyloidosis. We describe 4 cases of PH likely due to pulmonary vascular involvement and myocardial deposition from light chain deposition disease, amyloidosis, and multiple myeloma. On the basis of our clinical experience and literature review, we propose screening for plasma cell dyscrasia in patients with heart failure with preserved ejection fraction, unexplained PH, and hematological abnormalities. We also recommend inclusion of cardiopulmonary screening in patients with monoclonal gammopathy of undetermined significance.
url	http://www.sciencedirect.com/science/article/pii/S2542454820301879
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Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia

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