Differential Progression of Motor Dysfunction Between Male and Female Fragile X Premutation Carriers Reveals Novel Aspects of Sex-Specific Neural Involvement

Differential Progression of Motor Dysfunction Between Male and Female Fragile X Premutation Carriers Reveals Novel Aspects of Sex-Specific Neural Involvement

Expansions of the CGG repeat in the non-coding segment of the FMR1 X-linked gene are associated with a variety of phenotypic changes. Large expansions (>200 repeats), which cause a severe neurodevelopmental disorder, the fragile x syndrome (FXS), are transmitted from the mothers carrying smal...

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Bibliographic Details
Main Authors: Danuta Z. Loesch, Flora Tassone, Anna Atkinson, Paige Stimpson, Nicholas Trost, Dean L. Pountney, Elsdon Storey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
FMR1 premutation
CGG repeat
female carriers
motor scores
progression rates
gender differences
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.577246/full

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