Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice

Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice

Noise exposure of a short period at a moderate level can produce permanent cochlear synaptopathy without seeing lasting changes in audiometric threshold. However, due to the species differences in inner hair cell (IHC) calcium current that we have recently discovered, the susceptibility to noise exp...

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Bibliographic Details
Main Authors: Hongchao Liu, Hu Peng, Longhao Wang, Pengcheng Xu, Zhaoyan Wang, Huihui Liu, Hao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
noise-induced cochlear synaptopathy
calcium clearance
mitochondrial
inner hair cell
presynaptic ribbon
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.635201/full

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