Exploring the Molecular Basis for Substrate Affinity and Structural Stability in Bacterial GH39 β-Xylosidases

Exploring the Molecular Basis for Substrate Affinity and Structural Stability in Bacterial GH39 β-Xylosidases

The glycoside hydrolase family 39 (GH39) is a functionally expanding family with limited understanding about the molecular basis for substrate specificity and extremophilicity. In this work, we demonstrate the key role of the positive-subsite region in modulating substrate affinity and how the lack...

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Bibliographic Details
Main Authors: Mariana Abrahão Bueno de Morais, Carla Cristina Polo, Mariane Noronha Domingues, Gabriela Felix Persinoti, Renan Augusto Siqueira Pirolla, Flávio Henrique Moreira de Souza, Jessica Batista de Lima Correa, Camila Ramos dos Santos, Mário Tyago Murakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
glycoside hydrolase family 39
structural stability
substrate specificity
X-ray crystallography
Xanthomonas citri
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00419/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00419/full

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