Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio

Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio

The objectives of this work were the formulation optimization of the preparation process parameters and to evaluate spray-dried sustained-release microspheres using ammonio methacrylate copolymer (AMC) as a polymer matrix. The effects of log P and the concentrations of the cosolvents (acetone, methy...

Full description

Bibliographic Details
Main Authors: Piroska Szabó-Révész, Klára Pintye-Hódi, Péter Sipos, István Erős, Róbert Rajkó
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Pharmaceutics
Subjects:
microspheres
formulation optimization
cosolvents
drug/copolymer ratio
spray drying
factorial design study
Online Access:http://www.mdpi.com/1999-4923/3/4/830/

Internet

http://www.mdpi.com/1999-4923/3/4/830/

Similar Items