Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line

A series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an in vitro evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds 3f, 6f, 8c, and 10b showed IC50 values (6.53, 7.88, 7.89, 7.7...

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Main Authors:	Al-romaizan Abeer N., Jaber Thoraya S., Ahmed Nesreen S.
Format:	Article
Language:	English
Published:	De Gruyter 2019-11-01
Series:	Open Chemistry
Subjects:	1,8- naphthyridine pyrazole pyrimidine pyridine cytotoxic breast cancer
Online Access:	https://doi.org/10.1515/chem-2019-0097

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spelling	doaj-441eef4df1bc44258accd0a800ca3bc32021-09-06T19:19:36ZengDe GruyterOpen Chemistry2391-54202019-11-0117194395410.1515/chem-2019-0097chem-2019-0097Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell lineAl-romaizan Abeer N.0Jaber Thoraya S.1Ahmed Nesreen S.2Chemistry Dept., Faculty of Science, King Abdulaziz Universty, Jeddah, Saudi ArabiaChemistry Dept., Faculty of Science, King Abdulaziz Universty, Jeddah, Saudi ArabiaChemistry Dept., Faculty of Science, King Abdulaziz Universty, Jeddah, Saudi ArabiaA series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an in vitro evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds 3f, 6f, 8c, and 10b showed IC50 values (6.53, 7.88, 7.89, 7.79 μM, respectively) compared to that of the mentioned drug staurosparine (IC50 = 4.51 μM). On the other hand, derivatives 10c, 8d, 4d, 10f and 8b displayed better activity than staurosporin with IC50 values (1.47, 1.62, 1.68, 2.30, 3.19 μM, respectively).https://doi.org/10.1515/chem-2019-00971,8- naphthyridinepyrazolepyrimidinepyridinecytotoxicbreast cancer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Al-romaizan Abeer N. Jaber Thoraya S. Ahmed Nesreen S.
spellingShingle	Al-romaizan Abeer N. Jaber Thoraya S. Ahmed Nesreen S. Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line Open Chemistry 1,8- naphthyridine pyrazole pyrimidine pyridine cytotoxic breast cancer
author_facet	Al-romaizan Abeer N. Jaber Thoraya S. Ahmed Nesreen S.
author_sort	Al-romaizan Abeer N.
title	Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
title_short	Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
title_full	Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
title_fullStr	Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
title_full_unstemmed	Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
title_sort	novel 1,8-naphthyridine derivatives: design, synthesis and in vitro screening of their cytotoxic activity against mcf7 cell line
publisher	De Gruyter
series	Open Chemistry
issn	2391-5420
publishDate	2019-11-01
description	A series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an in vitro evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds 3f, 6f, 8c, and 10b showed IC50 values (6.53, 7.88, 7.89, 7.79 μM, respectively) compared to that of the mentioned drug staurosparine (IC50 = 4.51 μM). On the other hand, derivatives 10c, 8d, 4d, 10f and 8b displayed better activity than staurosporin with IC50 values (1.47, 1.62, 1.68, 2.30, 3.19 μM, respectively).
topic	1,8- naphthyridine pyrazole pyrimidine pyridine cytotoxic breast cancer
url	https://doi.org/10.1515/chem-2019-0097
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Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line

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